The 2023 MDPI Annual Report has
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13 pages, 1597 KiB  
Article
Precision Oncology: Circulating Microvesicles as New Biomarkers in a Very Early Stage of Colorectal Cancer
by Anastasios G. Kriebardis, Leonidas Chardalias, Christos Damaskos, Abraham Pouliakis, Nikolaos Garmpis, Sotirios P. Fortis, Aspasia Papailia, Christiana Sideri, Hara T. Georgatzakou, Effie G. Papageorgiou, Theodoros Pittaras, Gerasimos Tsourouflis, Marianna Politou, Ioannis Papaconstantinou, Dimitrios Dimitroulis and Serena Valsami
Cancers 2024, 16(10), 1943; https://doi.org/10.3390/cancers16101943 (registering DOI) - 20 May 2024
Abstract
Background: The release of microvesicles (MVs) is an essential phenomenon for inter-cellular signaling in health and disease. The role of MVs in cancer is multidimensional and includes cancer cell survival, proliferation, and invasion. In this prospective study, we analyzed MV levels in colorectal [...] Read more.
Background: The release of microvesicles (MVs) is an essential phenomenon for inter-cellular signaling in health and disease. The role of MVs in cancer is multidimensional and includes cancer cell survival, proliferation, and invasion. In this prospective study, we analyzed MV levels in colorectal cancer patients and assessed the importance of MV release in early-stage colorectal cancer and survival. Methods: This study included 98 patients and 15 controls. The characterization of MVs from human plasma was performed by flow cytometry using monoclonal antibodies. Results: The levels of total MVs and MUC-1-positive, tissue factor (TF)-positive, and endothelial cell-derived MVs (EMVs) were statistically significantly higher in the colon cancer patients than in the controls (p < 0.001). Furthermore, the subgroup of patients with very early-stage colorectal cancer also had statistically significant differences in the levels of the abovementioned MVs compared to the controls (p < 0.01). Highly differentiated tumors had lower levels of MUC-1-positive MVs (p < 0.02), EMVs (p < 0.002), and EMV/TF combinations (p < 0.001) versus those with tumors with low/intermediate differentiation. Conclusions: Our data demonstrate that the analysis of circulating MV levels in plasma could possibly become a tool for the early diagnosis of colon cancer at a very early stage of the disease. Full article
(This article belongs to the Special Issue Predictive Biomarkers for Colorectal Cancer)
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14 pages, 3184 KiB  
Article
Study on Quality Characteristic of Chebulae Fructus and Its Adulterants and Degradation Pathway of Hydrolyzable Tannins
by Jian Xu, Xiangdong Wang, Huijuan Yu, Xin Chai, Min Zhang, Hong-Hua Wu and Yuefei Wang
Molecules 2024, 29(10), 2399; https://doi.org/10.3390/molecules29102399 (registering DOI) - 20 May 2024
Abstract
Chebulae Fructus (CF) is known as one of the richest sources of hydrolyzable tannins (HTs). In this study, ultra-performance liquid chromatography coupled with a photodiode array detector method was established for simultaneous determination of the 12 common phenolcarboxylic and tannic constituents (PTCs). Using [...] Read more.
Chebulae Fructus (CF) is known as one of the richest sources of hydrolyzable tannins (HTs). In this study, ultra-performance liquid chromatography coupled with a photodiode array detector method was established for simultaneous determination of the 12 common phenolcarboxylic and tannic constituents (PTCs). Using this method, quantitative analysis was accomplished in CF and other four adulterants, including Terminaliae Belliricae Fructus, Phyllanthi Fructus, Chebulae Fructus Immaturus, and Canarii Fructus. Based on a quantitative analysis of the focused compounds, discrimination of CF and other four adulterants was successfully accomplished by hierarchical cluster analysis and principal component analysis. Additionally, the total contents of the 12 compounds that we focused on in this study were unveiled as 148.86 mg/g, 96.14 mg/g, and 18.64 mg/g in exocarp, mesocarp, and endocarp and seed of CF, respectively, and PTCs were witnessed to be the most abundant in the exocarp of CF. Noticeably, the HTs (chebulagic acid, chebulanin acid, chebulinic acid, and punicalagin) were observed to be ultimately degraded to chebulic acid, gallic acid, and ellagic acid during sunlight-drying of the fresh fruits. As a result, our study indicated that CF and its adulterants could be distinguished by the observed 12 PTCs, which were mainly distributed in the exocarp of the fruits. The HTs were prone to degrade into the three simple phenolcarboxylic acids during drying or processing, allowing us to obtain a more comprehensive understanding of the PTCs, with great significance in the improved quality of CF and related products. Full article
(This article belongs to the Section Analytical Chemistry)
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29 pages, 9097 KiB  
Review
Pseudo-Spin Symmetry and the Hints for Unstable and Superheavy Nuclei
by Jing Geng, Zhiheng Wang, Jia Liu, Jiajie Li and Wenhui Long
Symmetry 2024, 16(5), 631; https://doi.org/10.3390/sym16050631 (registering DOI) - 20 May 2024
Abstract
The pseudo-spin symmetry (PSS) provides an important angle to understand nuclear microscopic structure and the novel phenomena found in unstable nuclei. The relativistic Hartree–Fock (RHF) theory, that takes the important degrees of freedom associated with the π-meson and ρ-tensor (ρ [...] Read more.
The pseudo-spin symmetry (PSS) provides an important angle to understand nuclear microscopic structure and the novel phenomena found in unstable nuclei. The relativistic Hartree–Fock (RHF) theory, that takes the important degrees of freedom associated with the π-meson and ρ-tensor (ρ-T) couplings into account, provides an appropriate description of the PSS restoration in realistic nuclei, particularly for the pseudo-spin (PS) doublets with high angular momenta (l˜). The investigations of the PSS within the RHF theory are recalled in this paper by focusing on the effects of the Fock terms. Aiming at common artificial shell closures appearing in previous relativistic mean-field calculations, the mechanism responsible for the PSS restoration of high-l˜ orbits is stressed, revealing the manifestation of nuclear in-medium effects on the PSS, and thus, providing qualitative guidance on modeling the in-medium balance between nuclear attractions and repulsions. Moreover, the essential role played by the ρ-T coupling, that contributes mainly via the Fock terms, is introduced as combined with the relations between the PSS and various nuclear phenomena, including the shell structure and the evolution, novel halo and bubble-like phenomena, and the superheavy magicity. As the consequences of the nuclear force in complicated nuclear many-body systems, the PSS itself and the mechanism therein can not only deepen our understanding of nuclear microscopic structure and relevant phenomena, but also provide special insight into the nature of the nuclear force, which can further enrich our knowledge of nuclear physics. Full article
(This article belongs to the Special Issue Restoration of Broken Symmetries in the Nuclear Many-Body Problem)
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11 pages, 815 KiB  
Article
Relationship between Socioeconomic Status and Pro-Environmental Behavior: The Role of Efficacy Beliefs
by Ivana Vrselja, Lana Batinić and Mario Pandžić
Soc. Sci. 2024, 13(5), 273; https://doi.org/10.3390/socsci13050273 (registering DOI) - 20 May 2024
Abstract
Efficacy beliefs are important determinants of human behavior. In the context of social cognitive theory, the perception of collective efficacy is closely related to the individual perception of self-efficacy, which is influenced by socio-structural factors such as socioeconomic status (SES). Surprisingly, the relationship [...] Read more.
Efficacy beliefs are important determinants of human behavior. In the context of social cognitive theory, the perception of collective efficacy is closely related to the individual perception of self-efficacy, which is influenced by socio-structural factors such as socioeconomic status (SES). Surprisingly, the relationship between these variables has received little attention in the literature on environmental issues. Within the framework of social cognitive theory, the aim of this study was to investigate whether SES has a direct effect on pro-environmental behavior and whether it has an indirect effect via perceptions of self-efficacy and collective efficacy, in relation to climate change mitigation behavior. An online cross-sectional study was conducted using a quota sample of 1075 participants (51.9% women) aged 18–79 years. Participants reported their SES using objective and subjective measures, perceptions of their own and collective efficacy in mitigating climate change, and the frequency of their pro-environmental behaviors. Structural equation modeling revealed that the model with serial mediation effects of self-efficacy and collective efficacy between SES (both objective and subjective) and pro-environmental behaviors showed a good model fit. As expected, both objective and subjective SES had no direct effect on pro-environmental behavior. Surprisingly, neither objective nor subjective SES had an indirect effect (via efficacy beliefs) on pro-environmental behavior. However, both self-efficacy and collective efficacy were associated with pro-environmental behavior. These findings have practical implications for the development of strategies aimed at enhancing pro-environmental behavior. Full article
(This article belongs to the Section Social Economics)
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21 pages, 3708 KiB  
Review
A Systematic Review of Social Sustainability Indicators for Water Use along the Agricultural Value Chain
by Pascalina Matohlang Pilane, Henry Jordaan and Yonas T. Bahta
Hydrology 2024, 11(5), 72; https://doi.org/10.3390/hydrology11050072 (registering DOI) - 20 May 2024
Abstract
The concept of sustainable water use serves as an indicator of environmental, economic, and social pressure on freshwater resources globally; however, the social element of sustainability is not well researched within water-consumption studies. The objective of this paper is to consider the current [...] Read more.
The concept of sustainable water use serves as an indicator of environmental, economic, and social pressure on freshwater resources globally; however, the social element of sustainability is not well researched within water-consumption studies. The objective of this paper is to consider the current state of the literature on social sustainability indicators for water use in agriculture, as well as to describe the social (people) element of sustainability and establish water use as an element of society. By combining viewpoints, systematic literature reviews address research topics with a strength that no single work can have. From 314 papers published between 2013 and 2023, 42 papers were eligible for the review. This work employed a mixed-methods approach that included a systematic review following the (PRISMA) framework, scientific mapping through VOSviewer software (version 1.6.19), thematic reviews, and a review of the grey literature retrieved from artificial intelligence and deep learning technologies. The findings indicate that social sustainability indicators are based on environmental indicators. There are no set standards for what to consider as a social indicator of water use or for how these indictors can be measured. Life-cycle assessment and water-footprint assessment frameworks have shown progress with indicators that capture the social value of water such as productivity-reducing externalities, equity, and jobs per cubic metre of water. Full article
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30 pages, 3084 KiB  
Article
Environmental Management Framework for Road Network Demolition Wastes for Construction Industry of Pakistan
by Sajjad Shuker Ullah, Ishtiaq Hassan and Syed Shujaa Safdar Gardezi
Sustainability 2024, 16(10), 4302; https://doi.org/10.3390/su16104302 (registering DOI) - 20 May 2024
Abstract
Demolition waste from construction industry, especially from road networks, is one of the most voluminous and harmful categories of waste worldwide; therefore, its proper handling is essential for sustainable waste management for environmental, social, and economic benefits. Prolific and unregulated construction activities, conflicts, [...] Read more.
Demolition waste from construction industry, especially from road networks, is one of the most voluminous and harmful categories of waste worldwide; therefore, its proper handling is essential for sustainable waste management for environmental, social, and economic benefits. Prolific and unregulated construction activities, conflicts, and defective works are major reasons. The current work aims to address the issue by presenting a framework for an enhanced understanding of sustainable demolition waste management (DWM). A critical analysis of the literature aided to identify major concerns related to different causes, their impacts, and challenges being faced by the construction industry in such management endeavors. The study adopted questionnaire-based methodology to understand the critical relation among the three variables. The Delphi technique supported by industry professionals and pilot study helped to formulate a realistic questionnaire tool. Using the concept of multivariate statistical analysis, structure equation modeling (SEM) helped to assess the structural relationships between the three variables. The research instrument met the reliability, validity and internal consistency criteria required. Each variable achieved a high effect size, f2, with a value of co-efficient of determination of more than the threshold value of 70%. Thus, this supported the fitness criterion of the SEM-based measurement model. Path coefficients yielded the acceptance of all alternate hypotheses, resulting in a strong positive relationship among the three constructs. Therefore, demolition waste impacts are deemed as an effective mediator when explaining the impact between the other two variables. The developed framework presents a coherent and systematic approach and identifies strategies that could be used to address these issues and lead to DWM, including options available for capacity building and implementation and evaluation for supporting sustainability. Full article
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17 pages, 4280 KiB  
Article
EGFR and PI3K Signalling Pathways as Promising Targets on Circulating Tumour Cells from Patients with Metastatic Gastric Adenocarcinoma
by Ann-Katrin Piper, Chelsea Penney, Jacqueline Holliday, Gary Tincknell, Yafeng Ma, Sarbar Napaki, Klaus Pantel, Daniel Brungs and Marie Ranson
Int. J. Mol. Sci. 2024, 25(10), 5565; https://doi.org/10.3390/ijms25105565 (registering DOI) - 20 May 2024
Abstract
The prognosis for metastatic gastric adenocarcinoma (mGAC) remains poor. Gene alterations in receptor tyrosine kinases (RTKs) such as epidermal growth factor receptor (EGFR) and their downstream effectors including catalytic subunit alpha of the phosphatidylinositol 3-kinase (PIK3CA) are common in mGAC. Targeted RTK and [...] Read more.
The prognosis for metastatic gastric adenocarcinoma (mGAC) remains poor. Gene alterations in receptor tyrosine kinases (RTKs) such as epidermal growth factor receptor (EGFR) and their downstream effectors including catalytic subunit alpha of the phosphatidylinositol 3-kinase (PIK3CA) are common in mGAC. Targeted RTK and phosphatidylinositol-3-kinase (PI3K) treatments have demonstrated clinical benefits in other solid tumours and are key potential targets for clinical development against mGAC given the presence of recurrent alterations in these pathways. Furthermore, combination RTK/PI3K treatments may overcome compensatory mechanisms that arise using monotherapies, leading to improved patient outcomes. Herein, we investigated RTK/PI3K single and combination drug responses against our unique human mGAC-derived PIK3CA gain-of-function mutant, human epidermal growth factor receptor 2 (HER2)-negative, EGFR-expressing circulating tumour cell line, UWG02CTC, under two- and three-dimensional culture conditions to model different stages of metastasis. UWG02CTCs were highly responsive to the PI3K p110α-subunit targeted drugs PIK-75 (IC50 = 37.0 ± 11.1 nM) or alpelisib (7.05 ± 3.7 µM). Drug sensitivities were significantly increased in 3D conditions. Compensatory MAPK/ERK pathway upregulation by PI3K/Akt suppression was overcome by combination treatment with the EGFR inhibitor gefitinib, which was strongly synergistic. PIK-75 plus gefitinib significantly impaired UWG02CTC invasion in an organotypic assay. In conclusion, UWG02CTCs are a powerful ex vivo mGAC drug responsiveness model revealing EGFR/PI3K-targeted drugs as a promising combination treatment option for HER2-negative, RAS wild-type mGAC patients. Full article
(This article belongs to the Special Issue Molecular Advances in Gastric Cancer)
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18 pages, 8347 KiB  
Article
New Year Fireworks Influence on Air Quality in Case of Stagnant Foggy Conditions
by Audrė Kalinauskaitė, Lina Davulienė, Julija Pauraite, Agnė Minderytė and Steigvilė Byčenkienė
Urban Sci. 2024, 8(2), 54; https://doi.org/10.3390/urbansci8020054 (registering DOI) - 20 May 2024
Abstract
Urban science plays a pivotal role in understanding the complex interactions between fireworks, air quality, and urban environments. Dense firework smoke worsens air quality and poses a health hazard to the public. In this study, we show a situation where extremely foggy meteorological [...] Read more.
Urban science plays a pivotal role in understanding the complex interactions between fireworks, air quality, and urban environments. Dense firework smoke worsens air quality and poses a health hazard to the public. In this study, we show a situation where extremely foggy meteorological conditions coincided with intense anthropogenic emissions, including fireworks, in an urban area. For the first time, the chemical composition and sources of non-refractory submicron aerosol (NR-PM1) in outdoor and indoor air were characterized in Vilnius (Lithuania) using an aerosol chemical speciation monitor (ACSM) and Positive Matrix Factorization for the period before the fireworks, on New Year’s Eve, and after the fireworks in 2020/2021; thus, typical changes were assessed. Due to stagnant weather conditions and increased traffic, the highest concentrations of black carbon (BC) (13.8 μg/m3) were observed before the fireworks display. The contribution of organic (Org) fraction to the total NR-PM1 mass concentration, in the comparison of the values of a typical night and New Year’s Eve (from 9 p.m. to 6 a.m.), increased from 43% to 70% and from 47% to 60% in outdoor and indoor air, respectively. Biomass-burning organic aerosol (BBOA, 48% (44%)) and hydrocarbon-like organic aerosol (HOA, 35% (21%)) dominated the organic fraction indoors and outdoors, respectively. HOA was likely linked to increased traffic during the event, while BBOA may have been related to domestic heating and fireworks. Full article
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25 pages, 4991 KiB  
Article
Structural and Organizational Strategies of Locomotor Modules during Landing in Patients with Chronic Ankle Instability
by Tianle Jie, Datao Xu, Zanni Zhang, Ee-Chon Teo, Julien S. Baker, Huiyu Zhou and Yaodong Gu
Bioengineering 2024, 11(5), 518; https://doi.org/10.3390/bioengineering11050518 (registering DOI) - 20 May 2024
Abstract
Background: Human locomotion involves the coordinated activation of a finite set of modules, known as muscle synergy, which represent the motor control strategy of the central nervous system. However, most prior studies have focused on isolated muscle activation, overlooking the modular organization of [...] Read more.
Background: Human locomotion involves the coordinated activation of a finite set of modules, known as muscle synergy, which represent the motor control strategy of the central nervous system. However, most prior studies have focused on isolated muscle activation, overlooking the modular organization of motor behavior. Therefore, to enhance comprehension of muscle coordination dynamics during multi-joint movements in chronic ankle instability (CAI), exploring muscle synergies during landing in CAI patients is imperative. Methods: A total of 22 patients with unilateral CAI and 22 healthy participants were recruited for this research. We employed a recursive model for second-order differential equations to process electromyographic (EMG) data after filtering preprocessing, generating the muscle activation matrix, which was subsequently inputted into the non-negative matrix factorization model for extraction of the muscle synergy. Muscle synergies were classified utilizing the K-means clustering algorithm and Pearson correlation coefficients. Statistical parameter mapping (SPM) was employed for temporal modular parameter analyses. Results: Four muscle synergies were identified in both the CAI and healthy groups. In Synergy 1, only the gluteus maximus showed significantly higher relative weight in CAI compared to healthy controls (p = 0.0035). Synergy 2 showed significantly higher relative weights for the vastus lateralis in the healthy group compared to CAI (p = 0.018), while in Synergy 4, CAI demonstrated significantly higher relative weights of the vastus lateralis compared to healthy controls (p = 0.030). Furthermore, in Synergy 2, the CAI group exhibited higher weights of the tibialis anterior compared to the healthy group (p = 0.042). Conclusions: The study suggested that patients with CAI exhibit a comparable modular organizational framework to the healthy group. Investigation of amplitude adjustments within the synergy spatial module shed light on the adaptive strategies employed by the tibialis anterior and gluteus maximus muscles to optimize control strategies during landing in patients with CAI. Variances in the muscle-specific weights of the vastus lateralis across movement modules reveal novel biomechanical adaptations in CAI, offering valuable insights for refining rehabilitation protocols. Full article
(This article belongs to the Special Issue Advances in Trauma and Injury Biomechanics)
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12 pages, 581 KiB  
Review
The Public Health Approach to Oral Health: A Literature Review
by Mariel Cabrera, Raman Bedi and Marta Lomazzi
Oral 2024, 4(2), 231-242; https://doi.org/10.3390/oral4020019 (registering DOI) - 20 May 2024
Abstract
Background: Oral health (OH) has evolved beyond dental concerns to encompass psychosocial dimensions and overall well-being. This study reviews OH strategies within a public health framework to identify key elements for effective OH promotion. Methods: A literature review following PRISMA guidelines identified 42 [...] Read more.
Background: Oral health (OH) has evolved beyond dental concerns to encompass psychosocial dimensions and overall well-being. This study reviews OH strategies within a public health framework to identify key elements for effective OH promotion. Methods: A literature review following PRISMA guidelines identified 42 relevant articles from 62 screened. Five themes emerged: group-level, individual-level, policy-level (emphasizing devising OH policies), healthcare delivery, and communication. Common components included OH education, behaviour change, access to OH services, and policy integration. Results: Thematic analysis identified five overarching themes in oral health (OH) promotion strategies, with a focus on tailored approaches for specific populations and components such as education, access to services, interventions, and policy, emphasizing the multifaceted nature of OH promotion. Conclusion: Effective OH promotion requires a multifaceted approach and tailored strategies with interprofessional collaboration. Future research should focus on cost-effectiveness and user-friendly resources for OH professionals and policymakers. Full article
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18 pages, 2621 KiB  
Article
NDNOTA: NDN One-Time Authentication
by Manar Aldaoud, Dawood Al-Abri, Firdous Kausar and Medhat Awadalla
Information 2024, 15(5), 289; https://doi.org/10.3390/info15050289 (registering DOI) - 20 May 2024
Abstract
Named Data Networking (NDN) stands out as a prominent architectural framework for the future Internet, aiming to address deficiencies present in IP networks, specifically in the domain of security. Although NDN packets containing requested content are signed with the publisher’s signature which establishes [...] Read more.
Named Data Networking (NDN) stands out as a prominent architectural framework for the future Internet, aiming to address deficiencies present in IP networks, specifically in the domain of security. Although NDN packets containing requested content are signed with the publisher’s signature which establishes data provenance for content, the NDN domain still requires more holistic frameworks that address consumers’ identity verification while accessing protected contents or services using producer/publisher-preapproved authentication servers. In response, this paper introduces the NDN One-Time Authentication (NDNOTA) framework, designed to authenticate NDN online services, applications, and data in real time. NDNOTA comprises three fundamental elements: the consumer, producer, and authentication server. Employing a variety of security measures such as single sign-on (SSO), token credentials, certified asymmetric keys, and signed NDN packets, NDNOTA aims to reinforce the security of NDN-based interactions. To assess the effectiveness of the proposed framework, we validate and evaluate its impact on the three core elements in terms of time performance. For example, when accessing authenticated content through the entire NDNOTA process, consumers experience an additional time overhead of 70 milliseconds, making the total process take 83 milliseconds. In contrast, accessing normal content that does not require authentication does not incur this delay. The additional NDNOTA delay is mitigated once the authentication token is generated and stored, resulting in a comparable time frame to unauthenticated content requests. Additionally, obtaining private content through the authentication process requires 10 messages, whereas acquiring public data only requires two messages. Full article
(This article belongs to the Section Information Security and Privacy)
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17 pages, 60650 KiB  
Article
Autonomous Alignment and Docking Control for a Self-Reconfigurable Modular Mobile Robotic System
by Shumin Feng, Yujiong Liu, Isaac Pressgrove and Pinhas Ben-Tzvi
Robotics 2024, 13(5), 81; https://doi.org/10.3390/robotics13050081 (registering DOI) - 20 May 2024
Abstract
This paper presents the path planning and motion control of a self-reconfigurable mobile robot system, focusing on module-to-module autonomous docking and alignment tasks. STORM, which stands for Self-configurable and Transformable Omni-Directional Robotic Modules, features a unique mode-switching ability and novel docking mechanism design. [...] Read more.
This paper presents the path planning and motion control of a self-reconfigurable mobile robot system, focusing on module-to-module autonomous docking and alignment tasks. STORM, which stands for Self-configurable and Transformable Omni-Directional Robotic Modules, features a unique mode-switching ability and novel docking mechanism design. This enables the modules that make up STORM to dock with each other and form a variety configurations in or to perform a large array of tasks. The path planning and motion control presented here consists of two parallel schemes. A Lyapunov function-based precision controller is proposed to align the target docking mechanisms in a small range of the target position. Then, an optimization-based path planning algorithm is proposed to help find the fastest path and determine when to switch its locomotion mode in a much larger range. Both numerical simulations and real-world experiments were carried out to validate these proposed controllers. Full article
(This article belongs to the Special Issue Motion Trajectory Prediction for Mobile Robots)
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22 pages, 2560 KiB  
Article
ALMA Band 3 Source Counts: A Machine Learning Approach to Contamination Mitigation below 5 Sigma
by Ivano Baronchelli, Matteo Bonato, Gianfranco De Zotti, Viviana Casasola, Michele Delli Veneri, Fabrizia Guglielmetti, Elisabetta Liuzzo, Rosita Paladino, Leonardo Trobbiani and Martin Zwaan
Galaxies 2024, 12(3), 26; https://doi.org/10.3390/galaxies12030026 (registering DOI) - 20 May 2024
Abstract
We performed differential number counts down to 4.25 sigma using ALMA Band 3 calibrator images, which are known for their high dynamic range and susceptibility to various types of contamination. Estimating the fraction of contaminants is an intricate process due to correlated non-Gaussian [...] Read more.
We performed differential number counts down to 4.25 sigma using ALMA Band 3 calibrator images, which are known for their high dynamic range and susceptibility to various types of contamination. Estimating the fraction of contaminants is an intricate process due to correlated non-Gaussian noise, and it is often compounded by the presence of false positives generated during the cleaning phase. In addition, calibrator extensions further complicate the counting of background sources. In order to address these challenges, our strategy employs a machine learning-based approach utilizing the UMLAUT algorithm. UMLAUT assigns a value to each detection, and it considers how likely it is for there to be a genuine background source or a contaminant. With respect to this goal, we provide UMLAUT with eight observational input parameters, each automatically weighted using a gradient descent method. Our methodology significantly improves the precision of differential number counts, thus surpassing conventional techniques, including visual inspection. This study contributes to a better understanding of radio sources, particularly in the challenging sub-5 sigma regime, within the complex context of a high dynamic range of ALMA calibrator images. Full article
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9 pages, 1609 KiB  
Article
Complementary Thoracic Endovascular Aortic Repair (TEVAR) after Frozen Elephant Trunk for Residual Type A Aortic Dissection: Perioperative and Mid-Term Outcomes
by Spyridon N. Mylonas, Ravan Mammadov and Bernhard Dorweiler
J. Clin. Med. 2024, 13(10), 3007; https://doi.org/10.3390/jcm13103007 (registering DOI) - 20 May 2024
Abstract
Objectives: The aim of this retrospective study was to evaluate the results of complementary TEVAR following the frozen elephant trunk (FET) procedure for patients with residual type A aortic dissection (rTAAD) in terms of technical feasibility, safety and mid-term outcomes. Methods: This was [...] Read more.
Objectives: The aim of this retrospective study was to evaluate the results of complementary TEVAR following the frozen elephant trunk (FET) procedure for patients with residual type A aortic dissection (rTAAD) in terms of technical feasibility, safety and mid-term outcomes. Methods: This was a retrospective single-centre analysis of patients who received TEVAR after FET for rTAAD from January 2012 up to December 2021. The primary endpoint was technical success. Safety parameters included 30-day/in-hospital morbidity and mortality. Furthermore, mid-term clinical and morphological outcomes were evaluated. Results: Among 587 TEVAR procedures, 60 patients (11 with connective tissue disorders) who received TEVAR after FET for rTAAD were identified. The median interval between FET and TEVAR was 28.5 months. Indications for TEVAR after FET were true lumen collapse distal to FET prosthesis (n = 7), dSINE (n = 2), planned completion (n = 13) and aortic diameter progression (n = 38). In forty-seven patients, TEVAR was performed in an elective setting; eight and six patients were operated on in an urgent or emergency setting, respectively. All TEVAR procedures were successfully completed. The 30-day mortality and spinal cord ischemia rates were 1.7%. During a median follow-up of 37 months, two further patients died. Nine patients had to undergo a further aortic intervention: fenestrated stent-graft (n = 3) or open repair of the infrarenal abdominal aorta (n = 6). Conclusions: Complementary TEVAR following FET for rTAAD showed excellent technical success and low perioperative risk, supporting the feasibility and safety of this strategy. Despite the favourable mid-term survival, certain patients might require a further aortic procedure. Full article
(This article belongs to the Section Cardiovascular Medicine)
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22 pages, 4208 KiB  
Article
Numerical Modeling on Ballistic Impact Analysis of the Segmented Sandwich Composite Armor System
by Shah Alam and Papa Aboagye
Appl. Mech. 2024, 5(2), 340-361; https://doi.org/10.3390/applmech5020020 (registering DOI) - 20 May 2024
Abstract
This research delves into the design, modeling, and finite element impact analysis of the segmented sandwich composite armor system subjected to impact loading, considering different parameters such as materials to be used, armor height, and armor design configuration. Initial studies were performed to [...] Read more.
This research delves into the design, modeling, and finite element impact analysis of the segmented sandwich composite armor system subjected to impact loading, considering different parameters such as materials to be used, armor height, and armor design configuration. Initial studies were performed to select the ideal model that will provide the best impact resistance at the least weight and with minimal fabrication requirements. Material type, thickness, and overall model configuration were defined during the initial model development period. Once the final design was defined, finite element analysis was performed using 2017 ABAQUS software to observe the performance of the model and to validate the efficiency of the chosen armor. Based on the results from the material selection and thickness validation, the optimal design with the best impact resistance was noted as 1.2 mm thick rectangular segmented silicon carbide tiles, serving as the top layer that covers the three-level gradient core composed of a titanium metal honeycomb frame filled with silicon carbide inserts, and finally a 2 mm thick glass epoxy composite layer made from four laminas in a 0/45/90/-45-degree configuration serving as the last layer of the armor. Full article
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16 pages, 1486 KiB  
Article
Research on Aspect-Level Sentiment Analysis Based on Adversarial Training and Dependency Parsing
by Erfeng Xu, Junwu Zhu, Luchen Zhang, Yi Wang and Wei Lin
Electronics 2024, 13(10), 1993; https://doi.org/10.3390/electronics13101993 (registering DOI) - 20 May 2024
Abstract
Aspect-level sentiment analysis is used to predict the sentiment polarity of a specific aspect in a sentence. However, most current research cannot fully utilize semantic information, and the models lack robustness. Therefore, this article proposes a model for aspect-level sentiment analysis based on [...] Read more.
Aspect-level sentiment analysis is used to predict the sentiment polarity of a specific aspect in a sentence. However, most current research cannot fully utilize semantic information, and the models lack robustness. Therefore, this article proposes a model for aspect-level sentiment analysis based on a combination of adversarial training and dependency syntax analysis. First, BERT is used to transform word vectors and construct adjacency matrices with dependency syntactic relationships to better extract semantic dependency relationships and features between sentence components. A multi-head attention mechanism is used to fuse the features of the two parts, simultaneously perform adversarial training on the BERT embedding layer to enhance model robustness, and, finally, to predict emotional polarity. The model was tested on the SemEval 2014 Task 4 dataset. The experimental results showed that, compared with the baseline model, the model achieved significant performance improvement after incorporating adversarial training and dependency syntax relationships. Full article
(This article belongs to the Special Issue Advances in Social Bots)
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20 pages, 16712 KiB  
Article
Effects of Land Use/Cover Change on Terrestrial Carbon Stocks in the Yellow River Basin of China from 2000 to 2030
by Jiejun Zhang, Jie Yang, Pengfei Liu, Yi Liu, Yiwen Zheng, Xiaoyu Shen, Bingchen Li, Hongquan Song and Zongzheng Liang
Remote Sens. 2024, 16(10), 1810; https://doi.org/10.3390/rs16101810 (registering DOI) - 20 May 2024
Abstract
Accurately assessing and predicting the impacts of land use changes on ecosystem carbon stocks in the Yellow River Basin (YRB) and exploring the optimization of land use structure to increase ecosystem carbon stocks are of great practical significance for China to achieve the [...] Read more.
Accurately assessing and predicting the impacts of land use changes on ecosystem carbon stocks in the Yellow River Basin (YRB) and exploring the optimization of land use structure to increase ecosystem carbon stocks are of great practical significance for China to achieve the goal of “double carbon”. In this study, we used multi-year remote sensing data, meteorological data and statistical data to measure the ecosystem carbon stock in the YRB from 2000 to 2020 based on the InVEST model, and then simulated and measured the ecosystem carbon stock under four different land use scenarios coupled with the FLUS model in 2030. The results show that, from 2000 to 2020, urban expansion in the YRB continued, but woodland and grassland grew more slowly. Carbon stock showed an increasing trend during the first 20 years, with an overall increase of 7.2 megatons, or 0.23%. Simulating the four land use scenarios in 2030, carbon stock will decrease the most under the cropland protection scenario, with a decrease of 17.7 megatons compared with 2020. However, carbon stock increases the most under the ecological protection scenario, with a maximum increase of 9.1 megatons. Furthermore, distinct trends in carbon storage were observed across different regions, with significant increases in the upstream under the natural development scenario, in the midstream under the ecological protection scenario and in the downstream under the cropland protection scenario. We suggest that the upstream should maintain the existing development mode, with ecological protection prioritized in the middle reaches and farmland protection prioritized in the lower reaches. This study provides a scientific basis for the carbon balance, land use structure adjustment and land management decision-making in the YRB. Full article
(This article belongs to the Special Issue Assessment of Ecosystem Services Based on Satellite Data)
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14 pages, 2653 KiB  
Article
Osteophyte Cartilage as a Potential Source for Minced Cartilage Implantation: A Novel Approach for Articular Cartilage Repair in Osteoarthritis
by Shingo Kawabata, Tomoyuki Nakasa, Akinori Nekomoto, Dilimulati Yimiti, Shigeru Miyaki and Nobuo Adachi
Int. J. Mol. Sci. 2024, 25(10), 5563; https://doi.org/10.3390/ijms25105563 (registering DOI) - 20 May 2024
Abstract
Osteoarthritis (OA) is a common joint disorder characterized by cartilage degeneration, often leading to pain and functional impairment. Minced cartilage implantation (MCI) has emerged as a promising one-step alternative for large cartilage defects. However, the source of chondrocytes for MCI remains a challenge, [...] Read more.
Osteoarthritis (OA) is a common joint disorder characterized by cartilage degeneration, often leading to pain and functional impairment. Minced cartilage implantation (MCI) has emerged as a promising one-step alternative for large cartilage defects. However, the source of chondrocytes for MCI remains a challenge, particularly in advanced OA, as normal cartilage is scarce. We performed in vitro studies to evaluate the feasibility of MCI using osteophyte cartilage, which is present in patients with advanced OA. Osteophyte and articular cartilage samples were obtained from 22 patients who underwent total knee arthroplasty. Chondrocyte migration and proliferation were assessed using cartilage fragment/atelocollagen composites to compare the characteristics and regenerative potential of osteophytes and articular cartilage. Histological analysis revealed differences in cartilage composition between osteophytes and articular cartilage, with higher expression of type X collagen and increased chondrocyte proliferation in the osteophyte cartilage. Gene expression analysis identified distinct gene expression profiles between osteophytes and articular cartilage; the expression levels of COL2A1, ACAN, and SOX9 were not significantly different. Chondrocytes derived from osteophyte cartilage exhibit enhanced proliferation, and glycosaminoglycan production is increased in both osteophytes and articular cartilage. Osteophyte cartilage may serve as a viable alternative source of MCI for treating large cartilage defects in OA. Full article
(This article belongs to the Special Issue Molecular Mechanisms and Therapeutic Approaches to Osteoarthritis)
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21 pages, 5564 KiB  
Article
Bitcoin Volatility and Intrinsic Time Using Double-Subordinated Lévy Processes
by Abootaleb Shirvani, Stefan Mittnik, William Brent Lindquist and Svetlozar Rachev
Risks 2024, 12(5), 82; https://doi.org/10.3390/risks12050082 (registering DOI) - 20 May 2024
Abstract
We propose a doubly subordinated Lévy process, the normal double inverse Gaussian (NDIG), to model the time series properties of the cryptocurrency bitcoin. By using two subordinated processes, NDIG captures both the skew and fat-tailed properties of, as well as the intrinsic time [...] Read more.
We propose a doubly subordinated Lévy process, the normal double inverse Gaussian (NDIG), to model the time series properties of the cryptocurrency bitcoin. By using two subordinated processes, NDIG captures both the skew and fat-tailed properties of, as well as the intrinsic time driving, bitcoin returns and gives rise to an arbitrage-free option pricing model. In this framework, we derive two bitcoin volatility measures. The first combines NDIG option pricing with the Chicago Board Options Exchange VIX model to compute an implied volatility; the second uses the volatility of the unit time increment of the NDIG model. Both volatility measures are compared to the volatility based on the historical standard deviation. With appropriate linear scaling, the NDIG process perfectly captures the observed in-sample volatility. Full article
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15 pages, 861 KiB  
Article
Outcome after Intracerebral Haemorrhage and Decompressive Craniectomy in Older Adults
by Thomas Kapapa, Stefanie Jesuthasan, Frederike Schiller, Franziska Schiller, Marcel Oehmichen, Dieter Woischneck, Benjamin Mayer and Andrej Pala
Neurol. Int. 2024, 16(3), 590-604; https://doi.org/10.3390/neurolint16030044 (registering DOI) - 20 May 2024
Abstract
Objective: There is a relationship between the incidence of spontaneous intracerebral haemorrhage (ICH) and age. The incidence increases with age. This study aims to facilitate the decision-making process in the treatment of ICH. It therefore investigated the outcome after ICH and decompressive craniectomy [...] Read more.
Objective: There is a relationship between the incidence of spontaneous intracerebral haemorrhage (ICH) and age. The incidence increases with age. This study aims to facilitate the decision-making process in the treatment of ICH. It therefore investigated the outcome after ICH and decompressive craniectomy (DC) in older adults (>65 years of age). Methods: Retrospective, multicentre, descriptive observational study including only consecutive patients who received DC as the consequence of ICH. Additive evacuation of ICH was performed after the individual decision of the neurosurgeon. Besides demographic data, clinical outcomes both at discharge and 12 months after surgery were evaluated according to the Glasgow Outcome Scale (GOS). Patients were divided into age groups of ≤65 and >65 years and cohorts with favourable outcome (GOS IV–V) and unfavourable outcome (GOS I to III). Results: 56 patients were treated. Mean age was 53.3 (SD: 16.13) years. There were 41 (73.2%) patients aged ≤65 years and 15 (26.8%) patients aged >65 years. During hospital stay, 10 (24.4%) patients in the group of younger (≤65 years) and 5 (33.3%) in the group of older patients (>65 years) died. Mean time between ictus and surgery was 44.4 (SD: 70.79) hours for younger and 27.9 (SD: 41.71) hours for older patients. A disturbance of the pupillary function on admission occurred in 21 (51.2%) younger and 2 (13.3%) older patients (p = 0.014). Mean arterial pressure was 99.9 (SD: 17.00) mmHg for younger and 112.9 (21.80) mmHg in older patients. After 12 months, there was no significant difference in outcome between younger patients (≤65 years) and older patients (>65 years) after ICH and DC (p = 0.243). Nevertheless, in the group of younger patients (≤65 years), 9% had a very good and 15% had a good outcome. There was no good recovery in the group of older patients (>65 years). Conclusion: Patients >65 years of age treated with microsurgical haematoma evacuation and DC after ICH are likely to have a poor outcome. Furthermore, in the long term, only a few older adults have a good functional outcome with independence in daily life activities. Full article
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13 pages, 5480 KiB  
Article
The Complete Mitochondrial Genome of the Chemosymbiotic Lucinid Bivalve Pillucina pisidium (Dunker, 1860) Occurring in Seagrass Zostera marina Bed in a Lagoon in Jeju Island, Korea
by Jong-Seop Shin, Chi-une Song, Hyeongwoo Choi, Sung Hyun Yang, Kae Kyoung Kwon, Seong-il Eyun and Kwang-Sik Choi
J. Mar. Sci. Eng. 2024, 12(5), 847; https://doi.org/10.3390/jmse12050847 (registering DOI) - 20 May 2024
Abstract
Commonly found in tropic and subtropic seagrass beds, lucinid clams host sulfur-oxidizing bacteria within their gills. These symbionts are crucial in converting phytotoxic sulfide in the sediment into less harmful sulfate, thus enhancing the environment for seagrasses and associated biota. We recently uncovered [...] Read more.
Commonly found in tropic and subtropic seagrass beds, lucinid clams host sulfur-oxidizing bacteria within their gills. These symbionts are crucial in converting phytotoxic sulfide in the sediment into less harmful sulfate, thus enhancing the environment for seagrasses and associated biota. We recently uncovered small clams within a Zostera marina seagrass bed situated in a lagoon on Jeju Island, off the south coast of Korea. These bivalves, with shell lengths of up to 7 mm, exhibited distinct features, including thick and hypertrophied gills, inflated and ovoid shells with a shell height/shell length ratio of 0.99, and the absence of a sulcus on the external shell surface. These characteristics align closely with those of Pillucina pisidium, a lucinid clam species originally reported in Japan. Analysis of the cytochrome b gene partial sequences of the clams from Jeju Island revealed a 100% match with P. pisidium reported in Japan, confirming their identity. Moreover, we successfully assembled the complete mitochondrial genome of P. pisidium for the first time, revealing a circular genome spanning 21,059 bp. Additionally, we constructed a phylogenetic tree using 13 protein-coding genes (PCGs) extracted from the mitochondrial genome of P. pisidium. Notably, P. pisidium formed a distinct clade within the subclass Autobranchia alongside other lucinid clams in the phylogenetic tree. However, within the family Lucinidae, synteny analysis of the 13 PCGs revealed diverse gene arrangement patterns, indicating considerable divergence. This divergence underscores the need for an extensive examination of Lucinidae mitochondrial genomes to elucidate the phylogenetic ties more precisely within the family, highlighting P. pisidium’s distinct evolutionary path within the family Lucinidae. Full article
(This article belongs to the Special Issue Biodiversity and Population Ecology of Marine Invertebrates)
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22 pages, 877 KiB  
Article
Towards Media Monitoring: Detecting Known and Emerging Topics through Multilingual and Crosslingual Text Classification
by Jurgita Kapočiūtė-Dzikienė and Arūnas Ungulaitis
Appl. Sci. 2024, 14(10), 4320; https://doi.org/10.3390/app14104320 (registering DOI) - 20 May 2024
Abstract
This study aims to address challenges in media monitoring by enhancing closed-set topic classification in multilingual contexts (where both training and testing occur in several languages) and crosslingual contexts (where training is in English and testing spans all languages). To achieve this goal, [...] Read more.
This study aims to address challenges in media monitoring by enhancing closed-set topic classification in multilingual contexts (where both training and testing occur in several languages) and crosslingual contexts (where training is in English and testing spans all languages). To achieve this goal, we utilized a dataset from the European Media Monitoring webpage, which includes approximately 15,000 article titles across 18 topics in 58 different languages spanning a period of nine months from May 2022 to March 2023. Our research conducted comprehensive comparative analyses of nine approaches, encompassing a spectrum of embedding techniques (word, sentence, and contextual representations) and classifiers (trainable/fine-tunable, memory-based, and generative). Our findings reveal that the LaBSE+FFNN approach achieved the best performance, reaching macro-averaged F1-scores of 0.944 ± 0.015 and 0.946 ± 0.019 in both multilingual and crosslingual scenarios. LaBSE+FFNN’s similar performance in multilingual and crosslingual scenarios eliminates the need for machine translation into English. We also tackled the open-set topic classification problem by training a binary classifier capable of distinguishing between known and new topics with the average loss of ∼0.0017 ± 0.0002. Various feature types were investigated, reaffirming the robustness of LaBSE vectorization. The experiments demonstrate that, depending on the topic, new topics can be identified with accuracies above ∼0.796 and of ∼0.9 on average. Both closed-set and open-set topic classification modules, along with additional mechanisms for clustering new topics to organize and label them, are integrated into our media monitoring system, which is now used by our real client. Full article
(This article belongs to the Special Issue Natural Language Processing (NLP) and Applications—2nd Edition)
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18 pages, 4495 KiB  
Article
Marine Mammal Conflict Avoidance Method Design and Spectrum Allocation Strategy
by Han Wang, Jiawei Liu, Bingqi Liu and Yihu Xu
Electronics 2024, 13(10), 1994; https://doi.org/10.3390/electronics13101994 (registering DOI) - 20 May 2024
Abstract
Underwater wireless sensor networks play an important role in underwater communication systems. Communication through collaborative communication is an effective way to solve critical problems in underwater communication systems. Underwater sensors are often deployed in spaces that overlap with those of marine mammals, which [...] Read more.
Underwater wireless sensor networks play an important role in underwater communication systems. Communication through collaborative communication is an effective way to solve critical problems in underwater communication systems. Underwater sensors are often deployed in spaces that overlap with those of marine mammals, which can adversely affect them. For this reason, in this paper, a marine mammal conflict avoidance method that can be dynamically adjusted according to the channel idle time duration and sensor node demand is designed, and the derivation of the maximum occupancy time duration is performed. Meanwhile, in addition, combining the potential of reinforcement learning in adaptive management, efficient resource optimization, and solving complex problems, this study also proposes a reinforcement learning-based relay-assisted spectrum switching method (R2S), which aims to achieve a reasonable allocation of spectrum resources in relay collaborative communication systems. The experimental results show that the method proposed in this study can effectively reduce the disturbance to marine mammals while performing well in terms of conflict probability, interruption probability, and quality of service. Full article
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